Muscle Physiology Lab

Muscles are the most abundant tissue in the human body, and have a critical role in locomotion, energy expenditure and metabolic homeostasis. Our research program is dedicated to dissecting the cell biology and physiology of muscle, with a focus on the mechanisms underlying intracellular spatial organization, which is adapted to address the various functional demands of muscles. Mitochondria play a crucial role in signaling and energy distribution in muscle cells. However, the structure and functionality of mitochondrial networks deteriorate as muscle ages. Thus, we aim to understand the mechanisms driving the development and maintenance of mitochondrial networks in muscles, to help design strategies to improve muscle function and reverse age-induced mitochondrial dysfunction and muscle loss. Additionally, we investigate the structural, functional, and communicative aspects of mitochondria with endoplasmic reticulum in both physiological and pathophysiological conditions, such as diabetes and sarcopenia. We utilize a multidisciplinary approach, using genetic manipulation, molecular biology, 3D imaging (light and electron microscopy), and advanced metabolic imaging methods. By unraveling the complexities of mitochondrial function and its role in muscle health, we aim to contribute to the development of targeted therapies for age-related muscle disorders and metabolic diseases, ultimately improving the quality of life